A third of GPs are thinking about retiring from general practice in the next five years, according to a survey of thousands of doctors.
Nearly four in 10 (37%) said their workload was too much to deal with, while 53% said it was tough but generally manageable.
Two-thirds (68%) also told the British Medical Association (BMA) that they experienced significant work-related stress, but insisted they could deal with it.
Just one in six said they were unable to handle the stress of their job.
The BMA survey questioned 15,560 GPs and also found one in five trainees (19%) was already thinking about writing off work in the UK in favour of a job abroad.
The doctors' association said it raised doubts over political promises to dramatically boost GP numbers over the next five years.
Dr Chaand Nagpaul, BMA GP committee chair, said the survey painted a bleak picture of frustrated GPs facing "burnout" and swamped by "pointless paperwork".
"In this climate, it is absurd that in the recent leaders' debate, political parties were attempting to outbid each other on the number of GPs they could magically produce in the next parliament," said Dr Nagpaul.
The head of the Royal College of GPs went further and said the pressures on GPs posed a "genuine danger to patient safety".
Dr Maureen Baker said: "Highly trained and experienced GPs are leaving the profession in growing numbers because of the intense and increasing pressures that we are facing, and not enough medical students are entering general practice to replace them.
"This is a genuine danger to patient safety - and to the wellbeing of hardworking family doctors and our teams."
"We simply don't have enough GPs to cope with the increasing demand of our growing and ageing population," added Dr Baker.
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