Children who are given paracetamol could be at risk of developing asthma, according to a study.
Researchers from the University of Da Caruna in northern Spain asked parents of 10,371 children aged six and seven, and 10,372 children aged 13 and 14 if their children had asthma and how severe it was.
The parents were also asked how often they gave their children paracetamol in the last year and how often when they were infants.
Asthma can cause wheezing, coughing and shortness of breath Those in the younger age group given the medicine at least once a month were reportedly more than five times more times likely to have asthma while those given it just once a year were 70% more at risk.
But although the research suggested an association between paracetamol use and asthma symptoms, parents were advised not to automatically assume the drug causes asthma.
One health expert said parents should not be overly concerned by the research as there is still no conclusive evidence the drug is to blame.
Paracetamol is the main ingredient of several brands of children's liquid medicine sold in the UK, including Calpol, Medised, Disprol and Junior Parapaed.
Parents are advised to give children paracetamol in liquid form until the age of 12 when they can begin taking tablets.
One doctor said children with asthma could simply become ill more frequently and are thus given paracetamol more often by their parents.
Speaking in the Daily Mail, Dr Martin Scurr said: "It could be that children with asthma are more likely to get coughs and colds and then are given Calpol by their mothers.
"At the moment Calpol is the best we have and it's all we have so there is no reason to stop using it."
A spokesperson from the Medicines and Healthcare Regulatory Agency (MHRA), the UK drugs watchdog, said it was carefully reviewing the data and would consider whether to take any action.
Johnson & Johnson, the manufacturers of Calpol, said in a statement that they had reviewed the study and that did not demonstrate that paracetamol causes asthma.
"The possibility exists that children with asthma have a higher incidence of respiratory infections and thus a higher use of paracetamol," it said. "Calpol is proud of the 45 years of clinical history which supports its safety and efficacy."
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